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Schizophr Res. 2003 Dec 1;65(1):15-8.

The C270T polymorphism of the brain-derived neurotrophic factor gene is associated with schizophrenia.

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  • 1Department of Psychiatry, University of Szeged, Semmelweis u. 6., H-6725, Szeged, Hungary.


We investigated a novel polymorphism of single nucleotide substitution (C270T) of the brain-derived neurotrophic factor (BDNF) gene in schizophrenia patients (n=101) and in controls (n=68). The frequency of the C/T genotype and the T allele were significantly higher in the schizophrenia patients (25.7% and 13.9%, respectively) compared with the controls (5.9% and 2.9%). There were no significant differences in Positive and Negative Symptom Scale (PANSS) items and Global Assessment of Functioning (GAF) scores between the patients with C/C and C/T genotypes. Further studies are warranted to elucidate the significance of this finding in the pathophysiology of schizophrenia.

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