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Microbes Infect. 2003 Nov;5(13):1241-7.

Activation and suppression of the proinflammatory immune response by Vibrio cholerae toxins.

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Department of Microbiology-Immunology, Northwestern University Feinberg School of Medicine, 303 East Chicago Avenue, Morton 6-626, Chicago, IL 60611,USA.


Vibrio cholerae induces either non-inflammatory diarrhea or inflammatory gastroenteritis, depending on the presence of cholera toxin, a fluid secretion inducer and a modulator of host immunity. In the absence of cholera toxin, other toxins induce inflammation, resulting in gastroenteritis. Thus, multiple toxins likely affect the safety of live attenuated vaccines.

[Indexed for MEDLINE]

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