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Microbes Infect. 2003 Nov;5(13):1221-30.

The role of dendritic cells in immune responses against vaginal infection by herpes simplex virus type 2.

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Department of Epidemiology and Public Health and Immunobiology, Yale University School of Medicine, 60 College Street, LEPH 716, New Haven, CT 06510, USA.


Herpes simplex virus type 2 is a leading cause of genital ulcers that affects more women than men worldwide. Recent evidence indicates that protective immunity can be generated by specialized dendritic cells in the female genital mucosa. This article aims to provide an overview of the effector immunity required for protection from genital herpes, and to discuss the mechanism by which specific subsets of dendritic cells mediate induction of adaptive immunity following genital infection with herpes simplex virus type 2 in vivo.

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