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J Consult Clin Psychol. 2003 Dec;71(6):1058-67.

Cognitive therapy versus fluoxetine in generalized social phobia: a randomized placebo-controlled trial.

Author information

1
Department of Psychology, Institute of Psychiatry, London, United Kingdom. d.clark@iop.kcl.ac.uk

Abstract

Sixty patients meeting Diagnostic and Statistical Manual of Mental Disorders (4th ed.: American Psychiatric Association, 1994) criteria for generalized social phobia were assigned to cognitive therapy (CT), fluoxetine plus self-exposure (FLU + SE), or placebo plus self-exposure (PLA + SE). At posttreatment (16 weeks), the medication blind was broken. CT and FLU + SE patients then entered a 3-month booster phase. Assessments were at pretreatment, midtreatment, posttreatment, end of booster phase, and 12-month follow-up. Significant improvements were observed on most measures in all 3 treatments. On measures of social phobia, CT was superior to FLU + SE and PLA + SE at midtreatment and at posttreatment. FLU + SE and PLA + SE did not differ. CT remained superior to FLU + SE at the end of the booster period and at 12-month follow-up. On general mood measures, there were few differences between the treatments.

PMID:
14622081
DOI:
10.1037/0022-006X.71.6.1058
[Indexed for MEDLINE]

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