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J Clin Invest. 2003 Nov;112(10):1466-77.

The application of biofilm science to the study and control of chronic bacterial infections.

Author information

1
Center for Biofilm Engineering, Montana State University, Bozeman, Montana 59717-3980, USA. bill_c@erc.montana.edu

Erratum in

  • J Clin Invest. 2007 Jan;117(1):278.

Abstract

Unequivocal direct observations have established that the bacteria that cause device-related and other chronic infections grow in matrix-enclosed biofilms. The diagnostic and therapeutic strategies that have served us so well in the partial eradication of acute epidemic bacterial diseases have not yielded accurate data or favorable outcomes when applied to these biofilm diseases. We discuss the potential benefits of the application of the new methods and concepts developed by biofilm science and engineering to the clinical management of infectious diseases.

PMID:
14617746
PMCID:
PMC259139
DOI:
10.1172/JCI20365
[Indexed for MEDLINE]
Free PMC Article

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