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Br J Clin Pharmacol. 2003 Dec;56(6):588-99.

Pulmonary drug delivery. Part I: physiological factors affecting therapeutic effectiveness of aerosolized medications.

Author information

1
Department of Medicine at McMaster University, Hamilton, Ontario, Canada. labir@mcmaster.ca

Abstract

As the end organ for the treatment of local diseases or as the route of administration for systemic therapies, the lung is a very attractive target for drug delivery. It provides direct access to disease in the treatment of respiratory diseases, while providing an enormous surface area and a relatively low enzymatic, controlled environment for systemic absorption of medications. As a major port of entry, the lung has evolved to prevent the invasion of unwanted airborne particles from entering into the body. Airway geometry, humidity, mucociliary clearance and alveolar macrophages play a vital role in maintaining the sterility of the lung and consequently are barriers to the therapeutic effectiveness of inhaled medications. In addition, a drug's efficacy may be affected by where in the respiratory tract it is deposited, its delivered dose and the disease it may be trying to treat.

PMID:
14616418
PMCID:
PMC1884307
DOI:
10.1046/j.1365-2125.2003.01892.x
[Indexed for MEDLINE]
Free PMC Article

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