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Science. 2003 Dec 5;302(5651):1760-5. Epub 2003 Nov 13.

Inflammatory blockade restores adult hippocampal neurogenesis.

Author information

1
Stanford University, Department of Neurosurgery, MSLS P309, Mail Code 5487, 1201 Welch Road, Stanford, CA 94305-5487, USA.

Abstract

Cranial radiation therapy causes a progressive decline in cognitive function that is linked to impaired neurogenesis. Chronic inflammation accompanies radiation injury, suggesting that inflammatory processes may contribute to neural stem cell dysfunction. Here, we show that neuroinflammation alone inhibits neurogenesis and that inflammatory blockade with indomethacin, a common nonsteroidal anti-inflammatory drug, restores neurogenesis after endotoxin-induced inflammation and augments neurogenesis after cranial irradiation.

PMID:
14615545
DOI:
10.1126/science.1088417
[Indexed for MEDLINE]
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