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Immunity. 2003 Nov;19(5):701-11.

GATA-3 promotes maturation, IFN-gamma production, and liver-specific homing of NK cells.

Author information

1
Unité des Cytokines et Développement Lymphoïde, Inserm Equipe 101, Institut Pasteur, 75724 Paris, France.

Abstract

The GATA-3 transcription factor has a determinant role in T cell specification and is an essential mediator of T helper 2-type polarized immune responses. While both committed NK precursors and mature NK cells express GATA-3, a role of this transcription factor in murine NK cell differentiation is not known. We found that NK cells, in contrast to T cells, can be generated in the absence of GATA-3. However, while GATA-3 antagonizes IFN-gamma production in differentiating T cells, GATA-3-deficient NK cells paradoxically produced less IFN-gamma compared to control NK cells and failed to provide early protection in vivo against infection with Listeria monocytogenes. Surprisingly, GATA-3 was essential for NK cell homing to the liver. Our results suggest that GATA-3 promotes NK cell maturation and acts in this lineage to specify distinct effector phenotypes.

PMID:
14614857
DOI:
10.1016/s1074-7613(03)00294-2
[Indexed for MEDLINE]
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