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Immunity. 2003 Nov;19(5):641-4.

The IL-12 family of heterodimeric cytokines: new players in the regulation of T cell responses.

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Schering-Plough Research Institute, Laboratory for Immunological Research, 69571 Dardilly, France.


Originally the only known heterodimeric cytokine, IL-12 is now part of a family of five cytokines and shares important functions in the regulation of both innate and adaptive immunity with two of them, IL-23 and IL-27. Although initially these three cytokines were considered to have largely overlapping immunological functions, more recent studies, including two articles in this issue of Immunity (Hamano et al., 2003; Villarino et al., 2003), indicate that they mediate complex and well-differentiated functions.

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