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Cell Tissue Res. 2004 Feb;315(2):279-83. Epub 2003 Nov 12.

Human sperm associated antigen 4 (SPAG4) is a potential cancer marker.

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Monash Institute of Reproduction and Development and The ARC Centre of Excellence in Biotechnology and Development, Monash University, 3168 Melbourne, Australia.


Using a combination of database screening and polymerase chain reaction analyses we have determined the sequence and structure of the human sperm tail associated gene SPAG4. SPAG4 is a 12-exon gene spanning approximately 5.2 kb on chromosome 20q11.23. It is expressed in a limited number of normal tissues, notably the pancreas and testis, but is switched on and greatly upregulated in a wide range of neoplastic tissues. The data therefore strongly suggests that SPAG4 expression is a potential clinically relevant cancer marker.

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