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Cardiovasc Res. 2003 Nov 1;60(2):228-34.

Intrauterine undernutrition--renal and vascular origin of hypertension.

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Departamento de Farmacologia, Instituto de Ciências Biomédicas I (ICB-I), Universidade de São Paulo, 05508-900, Av Prof Lineu Prestes, 1524, sala 205, São Paulo, SP, Brazil.


A large number of clinical and experimental studies supports the hypothesis that intrauterine undernutrition is an important determinant of hypertension, coronary heart disease and non-insulin-dependent diabetes in the adult offspring. In this review, the renal and vascular repercussions of maternal undernutrition are emphasized, and the physiopatologic mechanisms discussed. The origin of hypertension is detailed based upon the findings of kidney functional parameters and endothelium function studies. A working model linking hypertension to intrauterine undernutrition is proposed.

[Indexed for MEDLINE]

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