Format

Send to

Choose Destination
Cancer Cell Int. 2003 Oct 14;3(1):17.

Tumor suppressor gene E-cadherin and its role in normal and malignant cells.

Author information

1
Department of Biology, School of Medicine, University of Zagreb, Salata 3, HR-10000 Zagreb, Croatia. nina@mef.hr

Abstract

E-cadherin tumor suppressor genes are particularly active area of research in development and tumorigenesis. The calcium-dependent interactions among E-cadherin molecules are critical for the formation and maintenance of adherent junctions in areas of epithelial cell-cell contact. Loss of E-cadherin-mediated-adhesion characterises the transition from benign lesions to invasive, metastatic cancer. Nevertheless, there is evidence that E-cadherins may also play a role in the wnt signal transduction pathway, together with other key molecules involved in it, such as beta-catenins and adenomatous poliposis coli gene products.The structure and function of E-cadherin, gene and protein, in normal as well as in tumor cells are reviewed in this paper.

Supplemental Content

Full text links

Icon for BioMed Central Icon for PubMed Central
Loading ...
Support Center