[Expression of HSD17beta2 gene in the fetal lung and placenta: control of sex steroid action]

Yves Tremblay; Pierre R Provost

doi:10.1051/medsci/20031910926

[Expression of HSD17beta2 gene in the fetal lung and placenta: control of sex steroid action]

Med Sci (Paris). 2003 Oct;19(10):926-30. doi: 10.1051/medsci/20031910926.

[Article in French]

Authors

Yves Tremblay¹, Pierre R Provost

Affiliation

¹ Unité d'Ontogénie et Reproduction, Centre hospitalier universitaire Laval (CHUL), Département d'Obstétrique et Gynécologie, Faculté de Médecine, Université Laval, 2705, boulevard Laurier, Sainte-Foy, Québec, G1V 4G2, Canada. yves.tremblay@crcuhl.ulaval.ca

PMID: 14613001
DOI: 10.1051/medsci/20031910926

Abstract

During gestation, sex steroids could potentially have detrimental effects on fetal development. At least two distinct mechanisms should prevent such effects. The 17beta-hydroxysteroid dehydrogenase-2 (HSD17beta2) plays a key role in each mechanism. Being expressed both in lung fibroblasts and placental endothelial cells, the HSD17beta2 should restrict testosterone and estradiol actions, thus enabling normal development.

Publication types

English Abstract
Review

MeSH terms

Embryonic and Fetal Development*
Estradiol / pharmacology*
Female
Fibroblasts / physiology
Gene Expression Regulation, Developmental*
Humans
Hydroxysteroid Dehydrogenases / biosynthesis*
Hydroxysteroid Dehydrogenases / genetics*
Lung / embryology
Lung / physiology
Male
Placenta / physiology
Testosterone / pharmacology*

Substances

Testosterone
Estradiol
Hydroxysteroid Dehydrogenases
3(17)-hydroxysteroid dehydrogenase