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Peptides. 2003 Aug;24(8):1099-107.

Selective toxicity of engineered lentivirus lytic peptides in a CF airway cell model.

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Division of Pediatric Pulmonology, The Children's Hospital of Pittsburgh, 3705 Fifth Avenue, 15213, Pittsburgh, PA, USA.


Lentivirus lytic peptides (LLPs) are derived from HIV-1 and have antibacterial properties. LLP derivatives (eLLPs) were engineered for greater potency against Staphylococcus aureus (SA) and Pseudomonas aeruginosa (PA). Minimum bactericidal concentration (MBC) was determined in low and physiologic salt concentrations. MBC was decreased against SA and equivalent against PA in physiologic salt when compared to the parent compound LLP1. In a novel cystic fibrosis (CF) airway cell model, one derivative, WLSA5, reduced the number of adherent PA and only moderately affected CF cell viability. Overall, eLLPs are selectively toxic to bacteria and may be useful against CF airway infections.

[Indexed for MEDLINE]

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