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J Cell Biol. 2003 Nov 10;163(3):437-40.

Traffic control: p120-catenin acts as a gatekeeper to control the fate of classical cadherins in mammalian cells.

Author information

1
Department of Biology and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-3280, USA. peifer@unc.edu

Abstract

Proteins of the p120 family have been implicated in the regulation of cadherin-based cell adhesion, but their relative importance in this process and their mechanism of action have remained less clear. Three papers in this issue suggest that p120 plays a key role in maintaining normal levels of cadherin in mammalian cells, and that it may do so by regulating cadherin trafficking (Chen et al., 2003; Davis et al., 2003; Xiao et al., 2003).

PMID:
14610049
PMCID:
PMC2173635
DOI:
10.1083/jcb.200310090
[Indexed for MEDLINE]
Free PMC Article
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