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Nat Immunol. 2003 Dec;4(12):1177-82. Epub 2003 Nov 9.

Deletion of beta-catenin impairs T cell development.

Author information

1
Dana Farber Cancer Institute, 44 Binney Street, Boston, Massachusetts 02115, USA.

Abstract

T cells encounter two main checkpoints during development in the thymus. These checkpoints are critically dependent on signals derived from the thymic microenvironment as well as from the pre-T cell receptor (pre-TCR) and the alphabeta TCR. Here we show that T cell-specific deletion of beta-catenin impaired T cell development at the beta-selection checkpoint, leading to a substantial decrease in splenic T cells. In addition, beta-catenin also seemed to be a target of TCR-CD3 signals in thymocytes and mature T cells. These data indicate that beta-catenin-mediated signals are required for normal T cell development.

PMID:
14608382
DOI:
10.1038/ni1008
[Indexed for MEDLINE]

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