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Trends Biochem Sci. 2003 Nov;28(11):576-80.

The CW domain, a structural module shared amongst vertebrates, vertebrate-infecting parasites and higher plants.

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1
Department of Molecular and Cellular Biology, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.

Abstract

A previously undetected domain, named CW for its conserved cysteine and tryptophan residues, appears to be a four-cysteine zinc-finger motif found exclusively in vertebrates, vertebrate-infecting parasites and higher plants. Of the twelve distinct nuclear protein families that comprise the CW domain-containing superfamily, only the microrchida (MORC) family has begun to be characterized. However, several families contain other domains suggesting a relationship between the CW domain and either chromatin methylation status or early embryonic development.

PMID:
14607086
DOI:
10.1016/j.tibs.2003.09.007
[Indexed for MEDLINE]
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