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World J Gastroenterol. 2003 Nov;9(11):2501-4.

Detection of serum anti-Helicobacter pylori immunoglobulin G in patients with different digestive malignant tumors.

Author information

1
School of Medicine, Anhui University of Science and Technology, Huainan, 232001, Anhui Province, China.

Abstract

AIM:

To investigate the seroprevalence of Helicobacter pylori infection in patients with different digestive malignant tumors.

METHODS:

Enzyme linked immunosorbent assay (ELISA) was used to detect serum anti-Helicobacter pylori IgG antibody in 374 patients with different digestive malignant tumors and 310 healthy subjects (normal control group).

RESULTS:

The seroprevalence of Helicobacter pylori infection was 61.50% (230/374) and 46.77% (145/310), respectively, in patients with digestive tumors and normal controls (P<0.05). The seroprevalence was 52.38% (33/63), 86.60% (84/97), 83.14% (84/101), 45.24 (19/42), 51.13% (18/35) and 44.44% (16/36), respectively in patients with carcinomas of esophagus, stomach, duodenum, rectum, colon and liver (P<0.01). In patients with intestinal and diffuse type gastric cancers, the seroprevalence was 93.75% (60/64) and 72.73% (24/33), respectively (P<0.05). In patients with gastric antral and cardiac cancers, the seroprevalence was 96.43% (54/56) and 73.17% (30/41), respectively (P<0.05). In patients with ulcerous and proliferous type duodenal cancers, the seroprevalence of H pylori infection was 91.04% (61/67) and 52.27% (23/44), respectively (P<0.05). In patients with duodenal bulb and descending cancers, the seroprevalence was 94.20% (65/69) and 45.20% (19/42), respectively (P<0.05).

CONCLUSION:

H pylori infection is associated with occurrence and development of gastric and duodenal carcinomas. Furthermore, it is also associated with histological type and locations of gastric and duodenal carcinomas.

PMID:
14606084
PMCID:
PMC4656528
DOI:
10.3748/wjg.v9.i11.2501
[Indexed for MEDLINE]
Free PMC Article

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