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J Hum Genet. 2003;48(12):668-71. Epub 2003 Nov 7.

Cloning and mutation analysis of ZFP276 as a candidate tumor suppressor in breast cancer.

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  • 1Program in Genetics and Genomics Biology, Research Institute, The Hospital for Sick Children, 555 University Ave, Toronto, Ontario, M5G 1X8, Canada.


Loss of heterozygosity (LOH) involving chromosome 16q23.4 occurs frequently in breast tumors, which suggests that this region may contain a tumor suppressor gene. Since ZFP276 is located in this region, we have therefore cloned and performed mutation analysis of its coding region in 70 breast tumors. One silent polymorphism and two alterations predicted to result in amino acid changes were detected. Absence of the wild-type allele in tumors carrying the E530D variant suggests a possible role for this change in tumorigenesis.

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