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Dis Colon Rectum. 2003 Nov;46(11):1555-9.

Treatment of grade III anal intraepithelial neoplasia with photodynamic therapy: report of a case.

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  • 1Department of Surgery and Molecular Oncology, Ninewells Hospital and Medical School, Dundee, United Kingdom.



We report the use of photodynamic therapy to treat a 53-year-old female with Grade III anal intraepithelial neoplasia.


Topical 5-aminolevulinic acid cream was applied to the affected area five hours before light treatment. The distribution of 5-aminolevulinic acid-induced protoporphyrin IX was identified by its characteristic red fluorescence. The lesion was treated by illumination with a 630-nm red laser light that used a total energy of 125 J/cm2 for approximately 17 minutes.


Complete symptomatic relief was achieved after the first photodynamic therapy session, and macroscopic and microscopic ablation of dysplasia was achieved after a second session of photodynamic therapy. Healing was excellent, with no residual scarring or functional loss.


Photodynamic therapy offers a simple, noninvasive method for treatment of anal intraepithelial neoplasia.

[PubMed - indexed for MEDLINE]
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