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J Clin Microbiol. 2003 Nov;41(11):5265-6.

Collaborative consensus for optimized multilocus sequence typing of Candida albicans.

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Unité Biologie et Pathogénicité Fongiques, CNRS URA 2172, Paris, France.


A panel of 86 different Candida albicans isolates was subjected to multilocus sequence typing (MLST) in two laboratories to obtain sequence data for 10 published housekeeping gene fragments. Analysis of data for all possible combinations of five, six, seven, eight, and nine of the fragments showed that a set comprising the fragments AAT1a, ACC1, ADP1, MPIb, SYA1, VPS13, and ZWF1b was the smallest that yielded 86 unique diploid sequence types for the 86 isolates. This set is recommended for future MLST with C. albicans.

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