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Trends Mol Med. 2003 Nov;9(11):455-7.

Trinucleotide repeat expansions: timing is everything.

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Molecular Genetics Program, Wadsworth Center, 120 New Scotland Avenue, Albany, NY 12208, USA.


The expansion of trinucleotide repeats is known to cause a growing number of human diseases. However, the mechanism and timing of expansions are poorly understood. Recent studies indicate that expansion mutations occur by multiple pathways during both meiotic and mitotic divisions, and at various stages of cell division. In addition, mismatch repair proteins play a major part in generating expansions.

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