Format

Send to

Choose Destination
J Org Chem. 2003 Nov 14;68(23):9126-8.

A short and efficient synthesis of crocetin-dimethylester and crocetindial.

Author information

1
Departamento de Química, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, 14040-901 Ribeirão Preto, SP, Brazil.

Abstract

In this paper we describe an efficient six-step synthesis of crocetin-dimethylester that could be further reduced to a "four-step" synthesis through the use of in situ procedures. The simplicity of the whole process, the ready availability of starting materials, and the high overall yield render this strategy a very attractive synthesis of this very important compound, which is the key intermediate for the synthesis of several carotenoids and other polyene natural products.

PMID:
14604394
DOI:
10.1021/jo034545y

Supplemental Content

Full text links

Icon for American Chemical Society
Loading ...
Support Center