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J Org Chem. 2003 Nov 14;68(23):9116-8.

A short and efficient synthesis of the pharmacological research tool GW501516 for the peroxisome proliferator-activated receptor delta.

Author information

1
Drug Discovery Program, Department of Neurology, Georgetown University Medical Center, 3900 Reservoir Road NW, Washington, D.C. 20057, USA.

Abstract

The most potent and selective peroxisome proliferator-activated receptor delta (PPARdelta) agonist GW501516 (1) was synthesized in 4 steps and 78% overall yield starting from o-cresol by using a one-pot regiocontrolled dialkylation of mercaptophenol 5 as the key step.

PMID:
14604391
DOI:
10.1021/jo035140g
[Indexed for MEDLINE]

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