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Rheum Dis Clin North Am. 2003 Nov;29(4):831-45.

Is time to joint replacement a valid outcome measure in clinical trials of drugs for osteoarthritis?

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Department of Rheumatology, Dijon University Hospital, INSERM ERIT-M 0207, Department of Rheumatology, University of Burgundy, Hôpital Général, Dijon, France.


Each of the five sets of criteria for THA mentioned in this article should be regarded as preliminary. They require validation in future studies conducted in various cohorts of patients and in different countries. Moreover, a set of generally accepted criteria is badly needed. The number of proposed sets of criteria listed in this article indicates clearly that no consensus presently exists with respect to the optimal time for a patient who has hip OA to undergo THA.

[Indexed for MEDLINE]

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