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Dev Cell. 2003 Nov;5(5):671-2.

Ribosomes rule: translation, not transcription, is the primary target of two major intercellular signaling pathways.

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Department of Biology, McGill University, Montréal, Québec, Canada.


Many investigations have focused on how signaling pathways influence the transcription of specific target genes. However, a new report by Rajasekhar et al. indicates that the Ras and Akt pathways have a much stronger influence on the association of mRNAs with polysomes than on the levels of those mRNAs themselves.

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