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Int J Cancer. 2003 Dec 20;107(6):873-7.

The IGF-1 receptor in cancer biology.

Author information

1
Kimmel Cancer Center, Thomas Jefferson University, 233 South 10th Street, 624 BLSB, Philadelphia, PA 19107, USA. b_lupo@mail.jci.tju.edu

Abstract

The type 1 insulin-like growth factor receptor (IGF-1R) plays an important role in the establishment and maintenance of the transformed phenotype. It also has a strong antiapoptotic activity and has a significant influence on the control of cell and body size. Downregulation of the IGF-1R leads to massive apoptosis of cancer cells. These characteristics make it an attractive target for anticancer therapy.

PMID:
14601044
DOI:
10.1002/ijc.11487
[Indexed for MEDLINE]
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