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Prostate. 2003 Dec 1;57(4):261-9.

Where are the prostate cancer genes?--A summary of eight genome wide searches.

Author information

1
Cancer Research U.K. Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Strangeways Research Laboratory, Worts Causeway, Cambridge, United Kingdom. douglas@srl.cam.ac.uk

Abstract

BACKGROUND:

There is strong evidence for genetic susceptibility to prostate cancer, but most of the genes underlying this susceptibility remain to be identified.

METHODS:

We reviewed the results of eight genome-wide linkage searches based on 1,293 families with multiple cases of prostate cancer.

RESULTS:

Across these studies, 11 linkage peaks with LOD scores in excess of 2 were identified. However, no chromosomal region was reported as significant at this level by more than one study and only one corresponded to a peak previously suggested by another group.

CONCLUSIONS:

These results indicate that prostate cancer is genetically complex, and that combined analyses of large family sets will be required to evaluate reliably the linkage evidence.

PMID:
14601022
DOI:
10.1002/pros.10300
[Indexed for MEDLINE]

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