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AIDS. 2003 Nov 21;17(17):2537-9.

In vitro infection of human primary adipose cells with HIV-1: a reassessment.

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1
Institut Cochin, INSERM U567/CNRS UMR8104/Université Paris 5-René Descartes, Département des Maladies Infectieuses, 22 rue Méchain, 75014 Paris, France.

Abstract

We reassessed the infection ability of human primary preadipocytes. The use of X4, R5 or VSV-G-pseudotyped viral particles indicated that viral entry is the limiting step. However, transfection with HIV-1 receptors restored efficient infection. Analyses of CD4, CXCR4 and CCR5 expression on preadipocytes and adipocytes revealed that receptor co-expression levels did not permit HIV-1 entry into adipose cells from all biopsies tested. We concluded that adipose tissue cannot be infected with HIV-1 in vivo.

[Indexed for MEDLINE]

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