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Gynecol Oncol. 2003 Nov;91(2):435-7.

A case of prolonged carboplatin therapy in a patient with carboplatin hypersensitivity.

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Case Western Reserve University and the Ireland Cancer Center, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, MacDonald Women's Hospital, University Hospitals of Cleveland, Cleveland, OH 44106, USA.



Platinum-containing chemotherapeutic drugs have high response rates yet are known to cause hypersensitivity reactions. Attempts have been made to rechallenge allergic patients with prolonged desensitization infusion regimens.


A female with advanced peritoneal cancer went into remission after six cycles of paclitaxel/cisplatin. Her cancer recurred 17 months later and she was treated with paclitaxel/carboplatin. A hypersensitivity reaction to carboplatin occurred during the fourth cycle and further carboplatin was withheld. With the second recurrence carboplatin was resumed using a prolonged desensitization regimen. The patient had a third recurrence and has recently completed cycle 15 of carboplatin for a total of 56 cycles.


A carboplatin desensitization regimen may allow patients with platinum-sensitive ovarian or peritoneal cancer to continue to benefit from its efficacy.

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