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Biochem Pharmacol. 2003 Nov 15;66(10):2049-52.

Expression of heme oxygenase-1 and regulation by cytokines in human osteoarthritic chondrocytes.

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Departamento de Farmacología, Universidad de Valencia, Avda. Vicent Andrés Estellés s/n, Burjassot, 46100 Valencia, Spain.


Heme oxygenase-1 (HO-1) is implicated in the protection against tissue injury. We investigated the expression of this protein in cartilage sections and chondrocytes obtained from osteoarthritic patients. HO-1 was immunodetected in preparations from cartilage and also in chondrocytes cultured in the absence of stimulation. We found that HO-1 can be modulated by cytokines since the pro-inflammatory cytokines interleukin (IL)-1beta, IL-17 and tumour necrosis factor-alpha (TNF-alpha) down-regulated this protein, whereas the anti-inflammatory cytokine IL-10 exerted the opposite effect. Our results suggest a role for HO-1 as part of protective mechanisms against tissue injury in human cartilage.

[Indexed for MEDLINE]

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