Format

Send to

Choose Destination
See comment in PubMed Commons below
Clin Chem Lab Med. 2003 Sep;41(9):1107-19.

Insulin resistant states and insulin signaling.

Author information

1
Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. peter.vollenweider@chuv.hospvd.ch

Abstract

The incidence of type 2 diabetes mellitus (T2D) and obesity is increasing rapidly worldwide, reaching epidemic proportions. Insulin resistance is a key feature in both conditions and plays an important pathophysiological role. Over the last two decades a central role in the origin of insulin resistance has emerged for defects in the intracellular insulin signaling cascade leading to glucose uptake. Herein, we will 1) review insulin signaling pathways leading to glucose uptake, 2) review mouse models of insulin resistance that demonstrate the pathophysiologic importance of specific defects of these pathways and 3) discuss the molecular basis for insulin resistance in some human disease states known to be associated with insulin resistance. Finally, we will briefly mention some novel treatment targets for T2D stemming from this knowledge.

PMID:
14598859
DOI:
10.1515/CCLM.2003.173
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for iFactory
    Loading ...
    Support Center