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J Clin Invest. 2003 Nov;112(9):1310-2.

The origin of FOXP3-expressing CD4+ regulatory T cells: thymus or periphery.

Author information

1
Department of Experimental Pathology, Institute for Frontier Medical Sciences, Kyoto University, 53 Shogin Kawahara-cho, Sakyo-ku, Kyoto 606-8507, Japan. shimon@frontier.kyoto-u.ac.jp

Abstract

Naturally arising CD4+ regulatory T cells, which engage in the maintenance of immunologic self-tolerance, specifically express FOXP3, which encodes a transcription-repressor protein. Genetic defects in FOXP3 cause IPEX, an X-linked autoimmune/inflammatory syndrome. With FOXP3 as a specific marker for regulatory CD4+ T cells in humans, it is now possible to determine their origin and developmental pathway.

PMID:
14597756
PMCID:
PMC228490
DOI:
10.1172/JCI20274
[Indexed for MEDLINE]
Free PMC Article

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