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Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13728-33. Epub 2003 Nov 3.

Neural correlates of training-related memory improvement in adulthood and aging.

Author information

1
Department of Psychology, Umeå University, S-901 87 Umeå, Sweden. lars.nyberg@psy.umu.se

Abstract

Cognitive studies show that both younger and older adults can increase their memory performance after training in using a visuospatial mnemonic, although age-related memory deficits tend to be magnified rather than reduced after training. Little is known about the changes in functional brain activity that accompany training-induced memory enhancement, and whether age-related activity changes are associated with the size of training-related gains. Here, we demonstrate that younger adults show increased activity during memory encoding in occipito-parietal and frontal brain regions after learning the mnemonic. Older adults did not show increased frontal activity, and only those elderly persons who benefited from the mnemonic showed increased occipito-parietal activity. These findings suggest that age-related differences in cognitive reserve capacity may reflect both a frontal processing deficiency and a posterior production deficiency.

PMID:
14597711
PMCID:
PMC263881
DOI:
10.1073/pnas.1735487100
[Indexed for MEDLINE]
Free PMC Article
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