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FASEB J. 2003 Nov;17(14):1986-95.

Cyclooxygenase-2 and 5-lipoxygenase converging functions on cell proliferation and tumor angiogenesis: implications for cancer therapy.

Author information

  • 1Department of Biomedical Sciences, University G. D'Annunzio, Ce.S.I., 66013 Chieti, Italy. mromano@unich.it

Abstract

Cyclooxygenase (COX) and lipoxygenase (LO) metabolic pathways are emerging as key regulators of cell proliferation and neo-angiogenesis. COX and LO inhibitors are being investigated as potential anticancer drugs and results from clinical trials seem to be encouraging. In this article we will review evidence of COX-2 and 5-LO involvement in cancer pathobiology, propose a model of integrated control of cell proliferation by these enzymes, and discuss the pharmacologic implications of this model.

PMID:
14597668
DOI:
10.1096/fj.03-0053rev
[PubMed - indexed for MEDLINE]
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