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Trends Immunol. 2003 Nov;24(11):589-94.

Hematopoietic stem cells: generation and manipulation.

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Department of Molecular Cell Biology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, 565-0871, Osaka, Japan.


Hematopoietic stem cells (HSCs) are at the forefront of both basic stem cell research and clinical applications. Regenerative medicine has recently become a viable form of therapy and can potentially cure several diseases. The generation of blood cells from embryonic stem cells and the manipulation of HSCs continue to provide insights into other stem cell systems. The importance of HSCs as a model of an ideal source for cell therapy is increasing.

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