Format

Send to

Choose Destination
Med Res Rev. 2004 Jan;24(1):40-89.

The thioredoxin system--from science to clinic.

Author information

1
Biochemie-Zentrum Heidelberg, Im Neuenheimer Feld 504, D-69120 Heidelberg, Germany. Stephan@gromer-online.de

Abstract

The thioredoxin system-formed by thioredoxin reductase and its characteristic substrate thioredoxin-is an important constituent of the intracellular redox milieu. Interactions with many different metabolic pathways such as DNA-synthesis, selenium metabolism, and the antioxidative network as well as significant species differences render this system an attractive target for chemotherapeutic approaches in many fields of medicine-ranging from infectious diseases to cancer therapy. In this review we will present and evaluate the preclinical and clinical results available today. Current trends in drug development are emphasized.

PMID:
14595672
DOI:
10.1002/med.10051
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center