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Ann Neurol. 2003 Nov;54(5):678-82.

Dually infected (HSV-1/VZV) single neurons in human trigeminal ganglia.

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  • 1Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians University, Marchioninistrasse 23, 81377 Munich, Germany.


Human trigeminal ganglia were tested by double fluorescence in situ hybridization for the presence and distribution of herpes simplex virus type 1 (HSV-1) and varicella-zoster virus (VZV) latency. Latency transcripts of both viruses were detected in common areas within the ganglia. Also, a few single neurons were shown to harbor HSV-1 and VZV together.

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