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Br J Psychiatry. 2003 Nov;183:414-7.

Size of hippocampal pyramidal neurons in schizophrenia.

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1
Department of Clinical Neurology, University of Oxford, UK.

Abstract

BACKGROUND:

Meta-analyses of hippocampal size have indicated that this structure is smaller in schizophrenia. This could reflect a reduction in the size of constituent neurons or a reduced number of neurons.

AIMS:

To measure the size of hippocampal pyramidal neurons in the brains of people with and without schizophrenia.

METHOD:

Pyramidal neuron size in hippocampal subfields was estimated stereologically from sections taken at 5 mm intervals throughout the whole length of right and left hippocampi from the brains of 13 people with schizophrenia and 16 controls. Results were assessed using repeated-measures analysis of covariance looking for a main effect of diagnosis and gender, and interactions of these with side.

RESULTS:

We were unable to detect significant differences related to diagnosis, gender or side for any hippocampal subfield for this series of cases.

CONCLUSIONS:

For this series of brains, hippocampal cell size is unchanged in schizophrenia.

PMID:
14594916
[Indexed for MEDLINE]
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