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Am J Psychiatry. 2003 Nov;160(11):2066-8.

Olanzapine effects on auditory sensory gating in schizophrenia.

Author information

1
Department of Psychiatry, Maryland Psychiatric Research Center, University of Maryland, Baltimore, MD 21228, USA.

Abstract

OBJECTIVE:

New-generation antipsychotics have been proposed to normalize the P50 sensory gating index in patients with schizophrenia. In the context of a double-blind comparison of olanzapine and haloperidol, the authors examined the effect of olanzapine on P50 suppression.

METHOD:

P50 measurements were obtained at baseline while patients were being treated with fluphenazine and after 12 weeks of double-blind treatment with either olanzapine (N=12) or haloperidol (N=12).

RESULTS:

There were no treatment group differences in P50 amplitude, latency, or sensory gating ratio.

CONCLUSIONS:

These results suggest that there is not a significant differential effect of olanzapine and haloperidol on the P50 sensory gating index in schizophrenia.

PMID:
14594761
DOI:
10.1176/appi.ajp.160.11.2066
[Indexed for MEDLINE]
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