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Prog Cell Cycle Res. 2003;5:489-95.

The interaction of glycogen synthase kinase-3 (GSK-3) with the cell cycle.

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MRC Laboratory for Molecular Cell Biology, Department of Biology, University College London, Gower St., WC1E 6BT, London, U.K.


GSK-3 is a multifunctional protein kinase known to play a pivotal role in the regulation of metabolism, the cytoskeleton and gene expression. It also interacts with the cell cycle in a number of ways. GSK-3 forms part of both Wnt and Hh signalling pathways and hence controls expression of a number of cell cycle regulatory genes. Prominent among these is cyclin D1. GSK-3 also phosphorylates cyclin D1 to promote its nuclear export and subsequent degradation. In this chapter we examine how GSK-3 mediates these effects and consider how therapeutic strategies may be developed to specifically target these pathways.

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