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Rev Neurol. 2003 Oct 16-31;37(8):758-65.

[Clinical and neuropsychological characteristics of Huntington's disease: a review].

[Article in Spanish]

Author information

1
Grupo de Neurociencias, Universidad de Antioquia, MedellĂ­n, Colombia. lasprilla50@hotmail.com

Abstract

INTRODUCTION:

Huntington's disease is a dominant autosomic neurodegenerative disorder. This article's objective is to provide an up-to-date description of the clinical and neuropsychological manifestations over the course of the disease.

METHOD:

According to clinical studies, the main characteristics of Huntington's disease include motor deficits, psychiatric problems and cognitive deficits. Many investigations have shown that a fronto-subcortical circuit dysfunction is responsible for these deficits. As the disease progresses, patients tend to have more cognitive difficulties which include attention/concentration problems, slowed cognitive processing, memory and language deficits, visuo-spatial problems and executive functioning difficulties.

CONCLUSION:

Studies with asymptomatic carriers of Huntington's disease have shown that cognitive deterioration may begin long before a clinical diagnosis of the disease is possible.

PMID:
14593636
[Indexed for MEDLINE]
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