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Eur J Clin Invest. 1992 Oct;22(10):687-91.

The effects of dietary supplementation with n-3 polyunsaturated fatty acids in patients with rheumatoid arthritis: a randomized, double blind trial.

Author information

1
Department of Rheumatology, Aalborg Hospital, Copenhagen, Denmark.

Abstract

STUDY OBJECTIVE:

To determine the effect of dietary supplementation with n-3 polyunsaturated fatty acids (n-3 PUFA) on disease variables in patients with rheumatoid arthritis.

DESIGN:

Multicenter, randomized, placebo controlled, double blind.

SETTING:

Three Danish hospital Departments of Rheumatology.

PATIENTS:

Fifty-one patients with active rheumatoid arthritis.

INTERVENTION:

Random allocation to 12 weeks of treatment with either six n-3 PUFA capsules (3.6 g) or six capsules with fat composition as the average Danish diet.

MAIN RESULTS:

Significant improvement of morning stiffness and joint tenderness. No significant effect on the four other assessed clinical parameters. No serious side effects.

CONCLUSIONS:

Dietary supplementation with n-3 PUFA in patients with rheumatoid arthritis improved two out of six patient reported disease parameters. Further studies are needed to clarify the more precise role of n-3 PUFA in the treatment of rheumatoid arthritis.

[Indexed for MEDLINE]

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