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J Bone Miner Metab. 2003;21(6):337-43.

The mechanism of osteoclast differentiation from macrophages: possible roles of T lymphocytes in osteoclastogenesis.

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Department of Biochemistry, Matsumoto Dental University, 1780 Hiro-oka Gobara, Shiojiri 399-0781, Japan.


Osteoclasts, which are present only in bone, are multinucleated giant cells with the capacity to resorb mineralized tissues. These osteoclasts are derived from hemopoietic progenitors of the monocyte-macrophage lineage. Osteoblasts are involved in osteoclastogenesis through a mechanism involving cell-to-cell contact with osteoclast progenitors. The recent discovery of osteoclast differentiation factor (ODF)/receptor activator of nuclear factor (NF)-KappaB ligand (RANKL) allowed elucidation of the precise mechanism by which osteoblasts regulate osteoclastic bone resorption. Synovial fibroblasts and activated T lymphocytes from patients with rheumatoid arthritis also express RANKL, which appears to trigger bone destruction in rheumatoid arthritis as well. Recent studies have shown that T lymphocytes produce cytokines other than RANKL, such as interleukin (IL)-17, granulocyte macrophage-colony stimulating factor (GM-CSF) and interferon (IFN)-Gamma, which have powerful regulatory effects on osteoclastogenesis. The possible roles of RANKL and other cytokines produced by T lymphocytes in osteoclast differentiation are described.

[Indexed for MEDLINE]

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