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Biochimie. 2003 Aug;85(8):721-6.

Serine/threonine protein phosphatases PP1 and PP2A are key players in apoptosis.

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URA CNRS 2581, D├ępartement de Parasitologie, Institut Pasteur, 25, rue du Dr Roux, 75015 Paris, France.


The reversible phosphorylation of proteins controlled by protein kinases and protein phosphatases is a major mechanism that regulates a wide variety of cellular processes. In contrast to C. elegans, recent studies in mammalian cells have highlighted a major role of serine/threonine protein phosphorylation in apoptosis. To illustrate the importance of dephosphorylation processes in apoptosis, this review will focus on recent studies suggesting that the interaction of the serine/threonine protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) with certain regulators of the Bcl-2 family is critically involved in the control of apoptosis.

[Indexed for MEDLINE]

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