Format

Send to

Choose Destination
See comment in PubMed Commons below
Neurochem Res. 2003 Nov;28(11):1735-42.

Stress and plasticity in the limbic system.

Author information

  • 1Department of Biological Sciences, Stanford University, Gilbert Laboratory, MC 5020, Stanford, California 94305-5020, USA. sapolsky@stanford.edu

Abstract

The adult nervous system is not static, but instead can change, can be reshaped by experience. Such plasticity has been demonstrated from the most reductive to the most integrated levels, and understanding the bases of this plasticity is a major challenge. It is apparent that stress can alter plasticity in the nervous system, particularly in the limbic system. This paper reviews that subject, concentrating on: a) the ability of severe and/or prolonged stress to impair hippocampal-dependent explicit learning and the plasticity that underlies it; b) the ability of mild and transient stress to facilitate such plasticity; c) the ability of a range of stressors to enhance implicit fear conditioning, and to enhance the amygdaloid plasticity that underlies it.

PMID:
14584827
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Support Center