Clearly, the determinants of depression in RA are complex and multifaceted. As with the disease itself, there is no simple cure for the depression that often accompanies it. Knowledge in this area is growing rapidly, however. Increasingly effective interventions are being developed to help those having difficulty adjusting to RA. As our understanding of the determinants of depression in RA increases, these therapies will continue to evolve. Ultimately, they may provide the long-term benefits desired by clinicians and patients alike.