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Proc Natl Acad Sci U S A. 2003 Nov 11;100(23):13632-7. Epub 2003 Oct 27.

Inflammation is detrimental for neurogenesis in adult brain.

Author information

1
Laboratory of Neurogenesis and Cell Therapy, Section of Restorative Neurology, Wallenberg Neuroscience Center, Biomedical Center A-11, Lund, Sweden.

Abstract

New hippocampal neurons are continuously generated in the adult brain. Here, we demonstrate that lipopolysaccharide-induced inflammation, which gives rise to microglia activation in the area where the new neurons are born, strongly impairs basal hippocampal neurogenesis in rats. The increased neurogenesis triggered by a brain insult is also attenuated if it is associated with microglia activation caused by tissue damage or lipopolysaccharide infusion. The impaired neurogenesis in inflammation is restored by systemic administration of minocycline, which inhibits microglia activation. Our data raise the possibility that suppression of hippocampal neurogenesis by activated microglia contributes to cognitive dysfunction in aging, dementia, epilepsy, and other conditions leading to brain inflammation.

PMID:
14581618
PMCID:
PMC263865
DOI:
10.1073/pnas.2234031100
[Indexed for MEDLINE]
Free PMC Article

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