Format

Send to

Choose Destination
J Virol. 2003 Nov;77(22):12373-7.

A bipartite late-budding domain in human immunodeficiency virus type 1.

Author information

1
Aaron Diamond AIDS Research Center, New York, New York, USA.

Abstract

Human immunodeficiency virus type 1 (HIV-1) encodes a PTAP motif within the p6 domain of Gag that recruits Tsg101 and associated factors to facilitate virion budding. In this study, we use trans-complementation assays to demonstrate that the PTAP motif acts synergistically with additional p6 sequences to mediate the formation of infectious extracellular HIV-1 virions. These studies suggest that Tsg101 recruitment is necessary but not sufficient to account for late-budding activity exhibited by HIV-1 p6.

PMID:
14581576
PMCID:
PMC254264
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center