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Trends Endocrinol Metab. 2003 Nov;14(9):398-403.

Lipid overload and overflow: metabolic trauma and the metabolic syndrome.

Author information

1
University of Texas Southwestern Medical Center, Dallas, TX 75390-8854, USA. roger.unger@UTSouthwestern.edu

Abstract

Approximately two-thirds of the US population are overweight, which means that insulin resistance is probably the most common metabolic abnormality in the USA. I propose three novel concepts concerning the causes and consequences of insulin resistance that challenge current thinking. First, there is the evidence that resistance to insulin-stimulated glucose metabolism is not a primary event in obesity, but is secondary to lipid accumulation resulting from full responsiveness to insulin-stimulated lipogenic activity. Second, resistance to insulin-stimulated glucose metabolism, now considered detrimental to health, might be a protective mechanism that reduces lipid-induced damage to tissue by excluding glucose from cells, thus decreasing glucose-derived lipogenesis. Third, I suggest that lipid-induced insulin resistance and the accompanying metabolic syndrome are secondary to leptin resistance, resulting in breakdown in the normal partitioning of surplus lipids in the adipocyte compartment.

PMID:
14580758
DOI:
10.1016/j.tem.2003.09.008
[Indexed for MEDLINE]

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